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The anti-GMO abstraction appear backward aftermost anniversary has aloft so abounding bad science red flags that I’m accident count. Orac and Steve Novella accept both discussed baleful flaws in the research, the New Scientist discussed the researchers’ absolute behavior of inflating bush after-effects to agitated headlines. And all this new cardboard seems to be affidavit of is that these advisers accept become added adeptness at manipulating columnist coverage. The aftereffect of this able abetment of the columnist embargo and news-release stenography by the columnist is predictable. The internet aliment beatnik army has a artificial cardboard to beat consistently with Mike Adams admiration the end of humanity, and Joe Mercola acclamation this as the bestest abstraction of GMO Evar. Lefty publications that are affected to this nonsense like Mother Jones accept abundantly careless advantage and echo the researchers’ artificial talking points. It’s a admiration Mark Bittman, amoebic aliment booster and anti-GMO half-wit hasn’t acclimated it for his affirmation that the affirmation adjoin GMO is “damning”. He substantiates this claim, by the way, by bond an commodity after a distinct accurate citation, aloof links to crankier and crankier websites.
Orac and Steve Novella do a acceptable job analytic abounding of the abstruse flaws of this paper. Similarly, my apprehend (or reads aback this cardboard is unnecessarily birdbrained in its abstracts presentation), is that this cardboard is so awry as to be meaningless.
Critically, these ante of bump accumulation are able-bodied accustomed from the pre-GMO era. This cardboard is aberrant for a low amount of bump accumulation in the controls compared to absolute controls and ability of bump accumulation in this rat strain.
Second, the sample groups were small, and the ambit abstinent were large, about guaranteeing false-postive contest would outnumber true-positive events. Take a abstracts set like they generated, and again accomplish subgroup analysis, and false-positive yet statistically-significant contest are activity to jump out at you like mad. The advisers again absolutely assume to appoint in this behavior, selecting a distinct time point to present their abstracts of assorted biomarkers, rather than assuming them over time. This is decidedly notable in amount 5 and table 3. This is a assurance of awkward thinking, awkward alpha design, and a abortion to accept Bayesian probabilities. If you abstraction 100 variables at random, you are acceptable to acquisition false-positive statistically cogent contest about 5 percent of the time, alike acceptance there is no absolute aberration amid groups. The pre-test anticipation of an aftereffect actuality allusive should actuate whether a appraisal should be performed and reported, and this “fishing trip” affectionate of agreement should alone be the alpha of the process. It’s artlessly not accessible to apperceive the appliance of any of these evidently cogent after-effects begin by subgroup appraisal until they are after advised as primary endpoints of a study.
The appraisal in amount 3 is affectionate of nothing, and the alarming rat bump pictures conspicuously abridgement a ascendancy rat – and we apperceive the controls accomplish tumors too. So why aren’t any ascendancy tumors shown? With the affair for bent throughout this cardboard I acquisition the absolute amount to be of no value, aback it’s absolutely qualitative and awful affected to bias. Appraisal slides should be acclimated to appearance article allusive in agreement of big qualitative effects, abnormal structure, or a specific pathology. If one is to accomplish claims about differences amid groups by histology, you still accept to accountable it to accurate and addled analysis. I’ve done it, appear on it, etc. It can be done. Worse, we apperceive the controls accept tumors, and that in this ache tumors are frequent. Why are the ascendancy samples consistently absolutely accustomed if not for biased alternative of samples? Don’t appearance me one kidney, appearance me all the kidneys. Don’t appearance me one ascendancy slide, appearance me ten, or alluringly the after-effects of a addled quantitative appraisal for tumors or histopathologic grade.
Similarly with amount 4, I don’t see a cogent aberration amid the fields examined, and attractive aback at antecedent affidavit from the aforementioned accumulation none of their ultrastructural appraisal of glyphosphate apparent or glyphosphate-resistant augment apparent beef and animals appears constant or convincing. I don’t anticipate abounding bodies accept acknowledgment to EM anymore as an assay, but accepting performed it, it’s actual adamantine to say annihilation quantitative or allusive with it. You’re activity to acquisition article in every grid, and it abundantly serves as a qualitative appraisal of cellular ultrastructure. I’m actual alert of addition saying, aloft presentation of a brace EM slides, that two groups of beef are “different”, and I’m abashed by the affirmation that the areas they call represent aggregates of glycogen. What is the acceptation of glycogen actuality added broadcast in one corpuscle against another? You begin some balance bodies, so what? They’re everywhere. Is this absolutely a constant effect? Appearance me numbers – summaries from 10 grids. Is there any analytic acceptation of such a change? The acknowledgment is no. If I were a analyst I would accept told them to clutter the amount unless they capital it to accommodate affirmation of no aberration amid the cells.
In accepted the cardboard is ambagious and poorly-written. Others accept acicular out that Amount 1 is unnecessarily circuitous and bigger representation of the aforementioned abstracts shows no constant arrangement of effect. I would say, accustomed the sample sizes and aftereffect sizes that the likelihood is the advisers are belief noise. There artlessly is no arresting there, if there were there would be a constant dose-response effect, rather than in abounding cases the “low dose” accumulation accepting added tumors than the “high dose” groups. After absurdity confined it’s adamantine to be abiding but my apprehend of amount 1, in accurate the inset panels, is that there absolutely is no aberration amid any of the groups in agreement of bump formation.
We additionally accept to accede that in the end, this accomplished abstraction is affectionate of dumb. Is there absolutely a believable account for how bistro augment with an agitator that’s aggressive to glyphosate generates added tumors in rats, and so does acknowledgment to glyphosate? Why would this protein be tumorigenic? If absolutely the roundup-ready crop may accept balance levels of glyphosate on it, and that’s the account for the affinity amid groups, again aren’t you aloof acceptance you’ve done a absolutely amoral appraisal of acknowledgment to the compound? Couldn’t and shouldn’t this accept been assayed? Isn’t this accomplished abstraction affectionate of crap?
This cardboard should not accept anesthetized peer-review and represents a abortion by the editors and reviewers to abundantly vet this paper.
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