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Turk, B. Targeting proteases: successes, failures and approaching prospects. Nature Rev. Biologic Discov. 5, 785–799 (2006).



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CAS  Google Scholar 

Smith, C. G. & Vane, J. R. The assay of captopril. FASEB J. 17, 788–789 (2003).

CAS  Google Scholar 



Flexner, C., Bate, G. & Kirkpatrick, P. Tipranavir. Nature Rev. Biologic Discov. 4, 955–956 (2005).

CAS  Google Scholar 

Melnikova, I. The anticoagulants market. Nature Rev. Biologic Discov. 8, 353–354 (2009).

CAS  Google Scholar 

Rawlings, N. D., Morton, F. R., Kok, C. Y., Kong, J. & Barrett, A. J. MEROPS: the peptidase database. Nucleic Acids Res. 36, D320–D325 (2008).

CAS  Google Scholar 

Timmer, J. C. et al. Structural and alive determinants of protease substrates. Nature Struct. Mol. Biol. 16, 1101–1108 (2009).

CAS  Google Scholar 

Davie, E. W. & Fujikawa, K. Basic mechanisms in claret coagulation. Annu. Rev. Biochem. 44, 799–829 (1975).

CAS  Google Scholar 

Davie, E. W. A abrupt actual assay of the waterfall/cascade of claret coagulation. J. Biol. Chem. 278, 50819–50832 (2003).

CAS  Google Scholar 

Peden, J. C. Jr & Mc Farland, J. A. Use of the claret thrombin time to appraise the capability of in vivo abatement of heparin: allusive studies afterward operations employing extracorporeal circulation. Claret 14, 1230–1236 (1959).

Google Scholar 

Bennett, B. & Ratnoff, O. D. The accustomed agglomeration mechanism. Med. Clin. North Am. 56, 95–104 (1972).

CAS  Google Scholar 

Turk, B., Turk, D. & Salvesen, G. S. Regulating cysteine protease activity: capital role of protease inhibitors as guardians and regulators. Curr. Pharm. Des 8, 1623–1637 (2002).

CAS  Google Scholar 

Van den Steen, P. E. et al. Biochemistry and atomic assay of gelatinase B or cast metalloproteinase-9 (MMP-9). Crit. Rev. Biochem. Mol. Biol. 37, 375–536 (2002).

CAS  PubMed  PubMed Central  Google Scholar 

McQuibban, G. A. et al. Inflammation abject by gelatinase A break of monocyte chemoattractant protein-3. Science 289, 1202–1206 (2000).

CAS  Google Scholar 

Overall, C. M. & Dean, R. A. Degradomics: systems assay of the protease web. Pleiotropic roles of MMPs in cancer. Blight Metastasis Rev. 25, 69–75 (2006).

Google Scholar 

Sabeh, F., Shimizu-Hirota, R. & Weiss, S. J. Protease-dependent versus-independent blight corpuscle aggression programs: three-dimensional amoeboid movement revisited. J. Corpuscle Biol. 185, 11–19 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Cauwe, B., Van den Steen, P. E. & Opdenakker, G. The biochemical, biological, and dissection kaleidoscope of corpuscle apparent substrates candy by cast metalloproteinases. Crit. Rev. Biochem. Mol. Biol. 42, 113–185 (2007).

CAS  Google Scholar 

Wolf, K., Muller, R., Borgmann, S., Brocker, E. B. & Friedl, P. Amoeboid appearance change and acquaintance guidance: T-lymphocyte ample through fibrillar collagen is absolute of cast adjustment by MMPs and added proteases. Claret 102, 3262–3269 (2003).

CAS  PubMed  Google Scholar 

Uhlmann, F., Wernic, D., Poupart, M. A., Koonin, E. V. & Nasmyth, M. Break of cohesin by the CD association protease separin triggers anaphase in yeast. Corpuscle 103, 375–386 (2000).

CAS  Google Scholar 

Kraft, C., Gmachl, M. & Peters, J. M. Methods to admeasurement ubiquitin-dependent proteolysis advised by the anaphase-promoting complex. Methods 38, 39–51 (2006).

CAS  Google Scholar 

Reyes-Turcu, F. E., Ventii, K. H. & Wilkinson, K. D. Adjustment and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu. Rev. Biochem. 78, 363–397 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Krishnaswamy, S. Exosite-driven substrate specificity and action in coagulation. J. Thromb. Haemost. 3, 54–67 (2005).

CAS  Google Scholar 

Rijken, D. C. & Lijnen, H. R. New insights into the atomic mechanisms of the fibrinolytic system. J. Thromb. Haemost. 7, 4–13 (2009).

CAS  Google Scholar 

Hu, J., Van den Steen, P. E., Sang, Q. X. & Opdenakker, G. Cast metalloproteinase inhibitors as assay for anarchic and vascular diseases. Nature Rev. Biologic Discov. 6, 480–498 (2007).

CAS  Google Scholar 

Dusing, R. & Sellers, F. ACE inhibitors, angiotensin receptor blockers and absolute renin inhibitors in combination: a assay of their role afterwards the ONTARGET trial. Curr. Med. Res. Opin. 25, 2287–2301 (2009).

Google Scholar 

Maisey, H. C., Doran, K. S. & Nizet, V. Recent advances in compassionate the atomic base of accumulation B Streptococcus virulence. Expert Rev. Mol. Med. 10, e27 (2008).

PubMed  PubMed Central  Google Scholar 

Imamura, T., Potempa, J. & Travis, J. Activation of the kallikrein–kinin arrangement and absolution of new kinins through another break of kininogens by microbial and animal corpuscle proteinases. Biol. Chem. 385, 989–996 (2004).

CAS  Google Scholar 

Adams, J. & Kauffman, M. Development of the proteasome inhibitor Velcade (Bortezomib). Blight Invest. 22, 304–311 (2004).

CAS  Google Scholar 

Green, D. R. & Evan, G. I. A amount of action and death. Blight Corpuscle 1, 19–30 (2002).

CAS  Google Scholar 

Mohamed, M. M. & Sloane, B. F. Cysteine cathepsins: multifunctional enzymes in cancer. Nature Rev. Blight 6, 764–775 (2006).

CAS  Google Scholar 

Schimmer, A. D. et al. Small-molecule antagonists of apoptosis suppressor XIAP affectation ample antitumor activity. Blight Corpuscle 5, 25–35 (2004).

CAS  PubMed  PubMed Central  Google Scholar 

Troy, C. M. & Salvesen, G. S. Caspases on the brain. J. Neurosci. Res. 69, 145–150 (2002).

CAS  Google Scholar 

Lopez-Otin, C. & Matrisian, L. M. Emerging roles of proteases in tumour suppression. Nature Rev. Blight 7, 800–808 (2007).

CAS  Google Scholar 

Lu, X., Lu, D., Scully, M. & Kakkar, V. ADAM proteins — ameliorative abeyant in cancer. Curr. Blight Biologic Targets. 8, 720–732 (2008).

CAS  Google Scholar 

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Palermo, C. & Joyce, J. A. Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol. Sci. 29, 22–28 (2008).

CAS  Google Scholar 

Mattos, C. et al. Multiple bread-and-butter clear structures: acerbic bounden sites, bendability and hydration. J. Mol. Biol. 357, 1471–1482 (2006).

CAS  Google Scholar 

Kim, D. et al. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin -7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally alive dipeptidyl peptidase IV inhibitor for the assay of blazon 2 diabetes. J. Med. Chem. 48, 141–151 (2005).

CAS  Google Scholar 

Kim, D. et al. Assay of almighty and careful dipeptidyl peptidase IV inhibitors acquired from β-aminoamides address subsituted triazolopiperazines. J. Med. Chem. 51, 589–602 (2008).

CAS  Google Scholar 

Leiting, B. et al. Catalytic backdrop and inhibition of proline-specific dipeptidyl peptidases, II, IV and VII. Biochem. J. 371, 525–532 (2003).

CAS  PubMed  PubMed Central  Google Scholar 

Rano, T. A. et al. A combinatorial access for free protease specificities: appliance to interleukin-1β converting agitator (ICE). Chem. Biol. 4, 149–155 (1997).

CAS  Google Scholar 

Wood, W. J., Patterson, A. W., Tsuruoka, H., Jain, R. K. & Ellman, J. A. Substrate action screening: a fragment-based adjustment for the accelerated identification of nonpeptidic protease inhibitors. J. Am. Chem. Soc. 127, 15521–15527 (2005).

CAS  Google Scholar 

Thompson, L. A. & Ellman, J. A. Synthesis and applications of baby atom libraries. Chem. Rev. 96, 555–600 (1996).

CAS  Google Scholar 

Schneider, E. L. & Craik, C. S. Positional scanning constructed combinatorial libraries for substrate profiling. Methods Mol. Biol. 539, 59–78 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Li, J. et al. Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus appliance tetrapeptide and octapeptide substrate libraries. J. Biol. Chem. 280, 28766–28774 (2005).

CAS  Google Scholar 

Backes, B. J., Harris, J. L., Leonetti, F., Craik, C. S. & Ellman, J. A. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to ascertain the continued substrate specificity of plasmin and thrombin. Nature Biotechnol. 18, 187–193 (2000).

CAS  Google Scholar 

Harris, J. L. et al. Accelerated and accepted profiling of protease specificity by appliance combinatorial fluorogenic substrate libraries. Proc. Natl Acad. Sci. USA 97, 7754–7759 (2000).

CAS  Google Scholar 

Drag, M. et al. Positional-scanning fluorigenic substrate libraries acknowledge abrupt specificity determinants of DUBs (deubiquitinating enzymes). Biochem. J. 415, 367–375 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Snipas, S. J., Drag, M., Stennicke, H. R. & Salvesen, G. S. Activation apparatus and substrate specificity of the Drosophila architect caspase DRONC. Corpuscle Afterlife Differ. 15, 938–945 (2008).

CAS  Google Scholar 

Choe, Y. et al. Substrate profiling of cysteine proteases appliance a combinatorial peptide library identifies functionally different specificities. J. Biol. Chem. 281, 12824–12832 (2006).

CAS  Google Scholar 

Brak, K., Doyle, P. S., McKerrow, J. H. & Ellman, J. A. Identification of a new chic of nonpeptidic inhibitors of cruzain. J. Am. Chem. Soc. 130, 6404–6410 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Inagaki, H. et al. Characterization and access of selective, nonpeptidic inhibitors of cathepsin S with an aberrant bounden mode. J. Med. Chem. 50, 2693–2699 (2007).

CAS  Google Scholar 

Melnikova, I. Hepatitis C therapies. Nature Rev. Biologic Discov. 7, 799–800 (2008).

CAS  Google Scholar 

Hu, J., Van den Steen, P. E., Dillen, C. & Opdenakker, G. Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects adjoin endotoxin shock. Biochem. Pharmacol. 70, 535–544 (2005).

CAS  PubMed  PubMed Central  Google Scholar 

Hu, J., Fiten, P., Van den Steen, P. E., Chaltin, P. & Opdenakker, G. Simulation of evolution-selected propeptide by high-throughput alternative of a peptidomimetic inhibitor on a capillary DNA sequencer platform. Anal. Chem. 77, 2116–2124 (2005).

CAS  Google Scholar 

Piccard, H. et al. “Reverse degradomics”, ecology of proteolytic accent by multi-CE and confocal apprehension of beaming substrates and acknowledgment products. Electrophoresis 30, 2366–2377 (2009).

CAS  Google Scholar 

Turk, B. E., Huang, L. L., Piro, E. T. & Cantley, L. C. Determination of protease break armpit motifs appliance mixture-based aggressive peptide libraries. Nature Biotechnol. 19, 661–667 (2001).

CAS  Google Scholar 

Turk, B. E. et al. MMP-20 is predominately a tooth-specific agitator with a abysmal catalytic abridged that hydrolyzes blazon V collagen. Biochemistry 45, 3863–3874 (2006).

CAS  PubMed  PubMed Central  Google Scholar 

Turk, B. E. et al. The structural base for substrate and inhibitor selectivity of the anthrax baleful factor. Nature Struct. Mol. Biol. 11, 60–66 (2004).

CAS  Google Scholar 

Watzke, A. et al. Careful activity-based probes for cysteine cathepsins. Angew. Chem. Int. Edn Engl. 47, 406–409 (2008).

CAS  Google Scholar 

Matthews, D. J. & Wells, J. A. Substrate phage: alternative of protease substrates by monovalent phage display. Science 260, 1113–1117 (1993).

CAS  Google Scholar 

Hansen, M. et al. A urokinase-type plasminogen activator-inhibiting circadian peptide with an abnormal P2 balance and an continued protease bounden apparent demonstrates new modalities for agitator inhibition. J. Biol. Chem. 280, 38424–38437 (2005).

CAS  Google Scholar 

Scholle, M. D. et al. Mapping protease substrates by appliance a biotinylated phage substrate library. Chembiochem 7, 834–838 (2006).

CAS  Google Scholar 

Timmer, J. C. & Salvesen, G. S. Caspase substrates. Corpuscle Afterlife Differ. 14, 66–72 (2007).

CAS  Google Scholar 

Impens, F. et al. MS-driven protease substrate degradomics. Proteomics 10, 1284–1296 (2010).

CAS  PubMed  PubMed Central  Google Scholar 

Chen, X. et al. Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b acquire antimalarial activity. Proc. Natl Acad. Sci. USA 103, 14548–14553 (2006).

CAS  Google Scholar 

Pellecchia, M. et al. Perspectives on NMR in biologic discovery: a address comes of age. Nature Rev. Biologic Discov. 7, 738–745 (2008).

CAS  Google Scholar 

Erlanson, D. A. et al. In situ accumulation of agitator inhibitors appliance continued tethering. Nature Biotechnol. 21, 308–314 (2003).

CAS  Google Scholar 

Eckelman, B. P., Salvesen, G. S. & Scott, F. L. Animal inhibitor of apoptosis proteins: why XIAP is the atramentous sheep of the family. EMBO Rep. 7, 988–994 (2006).

CAS  PubMed  PubMed Central  Google Scholar 

Rydel, T. J. et al. The anatomy of a circuitous of recombinant hirudin and animal α-thrombin. Science 249, 277–280 (1990).

CAS  Google Scholar 

Wada, C. K. The change of the cast metalloproteinase inhibitor biologic assay affairs at Abbott laboratories. Curr. Top. Med. Chem. 4, 1255–1267 (2004).

CAS  Google Scholar 

Wang, J. et al. Bump abolishment by a rationally advised capricious inhibitor of methionine aminopeptidase-2. Blight Res. 63, 7861–7869 (2003).

CAS  Google Scholar 

Forino, M. et al. Able constructed inhibitors of anthrax baleful factor. Proc. Natl Acad. Sci. USA 102, 9499–9504 (2005).

CAS  Google Scholar 

Hardy, J. A., Lam, J., Nguyen, J. T., O’Brien, T. & Wells, J. A. Assay of an allosteric armpit in the caspases. Proc. Natl Acad. Sci. USA 101, 12461–12466 (2004).

CAS  Google Scholar 

Herman, G. A., Stein, P. P., Thornberry, N. A. & Wagner, J. A. Dipeptidyl peptidase-4 inhibitors for the assay of blazon 2 diabetes: focus on sitagliptin. Clin. Pharmacol. Ther. 81, 761–767 (2007).

CAS  Google Scholar 

McKerrow, J. H., Engel, J. C. & Caffrey, C. R. Cysteine protease inhibitors as chemotherapy for abject infections. Bioorg Med. Chem. 7, 639–644 (1999).

CAS  Google Scholar 

Renatus, M. et al. Structural base of ubiquitin acceptance by the deubiquitinating protease USP2. Anatomy 14, 1293–1302 (2006).

CAS  Google Scholar 

Mikolajczyk, J. et al. Baby ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of animal SENPs. J. Biol. Chem. 282, 26217–26224 (2007).

CAS  Google Scholar 

Drag, M., Mikolajczyk, J., Krishnakumar, I. M., Huang, Z. & Salvesen, G. S. Action profiling of animal deSUMOylating enzymes (SENPs) with constructed substrates suggests an abrupt specificity of two anew characterized associates of the family. Biochem. J. 409, 461–469 (2008).

CAS  Google Scholar 

Reyes-Turcu, F. E. et al. The ubiquitin bounden area ZnF UBP recognizes the C-terminal diglycine burden of afloat ubiquitin. Corpuscle 124, 1197–1208 (2006).

CAS  Google Scholar 

Kornacker, M. G. et al. An inhibitor bounden abridged audible from the catalytic alive armpit on animal β-APP cleaving enzyme. Biochemistry 44, 11567–11573 (2005).

CAS  Google Scholar 

Shahian, T. et al. Inhibition of a viral agitator by a small-molecule dimer disruptor. Nat. Chem. Biol. 5, 640–646 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Schweizer, A. et al. Inhibition of caspase-2 by a advised ankyrin echo protein: specificity, structure, and inhibition mechanism. Anatomy 15, 625–636 (2007).

CAS  Google Scholar 

Thornberry, N. A. et al. A combinatorial access defines specificities of associates of the caspase ancestors and granzyme B. Functional relationships accustomed for key mediators of apoptosis. J. Biol. Chem. 272, 17907–17911 (1997).

CAS  Google Scholar 

Silverman, G. A. et al. The serpins are an accretion superfamily of structurally agnate but funtionally assorted proteins: evolution, apparatus of inhibition, atypical functions, and a revised nomenclature. J. Biol. Chem. 276, 33293–33296 (2001).

CAS  Google Scholar 

Brennan, S. Revisiting α1-antitrypsin assay in cystic fibrosis: can it still action promise? Eur. Respir. J. 29, 229–230 (2007).

CAS  Google Scholar 

Stoop, A. A. & Craik, C. S. Engineering of a macromolecular arch to advance specific protease inhibitors. Nature Biotechnol. 21, 1063–1068 (2003).

CAS  Google Scholar 

Dennis, M. S., Herzka, A. & Lazarus, R. A. Almighty and careful Kunitz area inhibitors of claret kallikrein advised by phage display. J. Biol. Chem. 270, 25411–25417 (1995).

CAS  Google Scholar 

Levy, J. H. & O’Donnell, P. S. The ameliorative abeyant of a kallikrein inhibitor for alleviative ancestral angioedema. Expert Opin. Investig. Drugs 15, 1077–1090 (2006).

CAS  Google Scholar 

Xuan, J. A. et al. Antibodies acrid hepsin protease action do not appulse corpuscle advance but arrest aggression of prostate and ovarian bump beef in culture. Blight Res. 66, 3611–3619 (2006).

CAS  Google Scholar 

Sun, J., Pons, J. & Craik, C. S. Almighty and careful inhibition of membrane-type serine protease 1 by animal single-chain antibodies. Biochemistry 42, 892–900 (2003).

CAS  Google Scholar 

Devy, L. et al. Careful inhibition of cast metalloproteinase-14 blocks bump growth, invasion, and angiogenesis. Blight Res. 69, 1517–1526 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Lazarus, R. A., Olivero, A. G., Eigenbrot, C. & Kirchhofer, D. Inhibitors of tissue factor. Agency VIIa for anticoagulant therapy. Curr. Med. Chem. 11, 2275–2290 (2004).

CAS  Google Scholar 

Chang, M.W. et al. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochem J. 429, 527–532 (2010).

CAS  PubMed  PubMed Central  Google Scholar 

Brenke, R. et al. Fragment-based identification of druggable ‘hot spots’ of proteins appliance Fourier area alternation techniques. Bioinformatics 25, 621–627 (2009).

CAS  PubMed  PubMed Central  Google Scholar 

Bogoyevitch, M. A. & Fairlie, D. P. A new archetype for protein kinase inhibition: blocking phosphorylation afterwards anon targeting ATP binding. Biologic Discov. Today 12, 622–633 (2007).

CAS  Google Scholar 

Conn, P. J., Christopoulos, A. & Lindsley, C. W. Allosteric modulators of GPCRs: a atypical access for the assay of CNS disorders. Nature Rev. Biologic Discov. 8, 41–54 (2009).

CAS  Google Scholar 

Goodey, N. M. & Benkovic, S. J. Allosteric adjustment and catalysis appear via a accepted route. Nat. Chem. Biol. 4, 474–482 (2008).

CAS  Google Scholar 

Falati, S., Gross, P., Merrill-Skoloff, G., Furie, B. C. & Furie, B. Real-time in vivo imaging of platelets, tissue agency and fibrin during arterial array accumulation in the mouse. Nature Med. 8, 1175–1181 (2002).

CAS  Google Scholar 

Girolami, A., Randi, M. L., Gavasso, S., Lombardi, A. M. & Spiezia, F. The casual venous thromboses apparent in patients with astringent (homozygous) FXII absence are apparently due to associated accident factors: a abstraction of prevalence in 21 patients and assay of the literature. J. Thromb. Thrombolysis 17, 139–143 (2004).

CAS  Google Scholar 

Baglia, F. A. & Walsh, P. N. Thrombin-mediated acknowledgment activation of agency XI on the activated platelet apparent is adopted over acquaintance activation by agency XIIa or agency XIa. J. Biol. Chem. 275, 20514–20519 (2000).

CAS  Google Scholar 

Renné, T. & Gailani, D. Role of agency XII in hemostasis and thrombosis: analytic implications. Expert Rev. Cardiovasc. Ther. 5, 733–741 (2007).

Google Scholar 

Duncan, R. C., Wijeyewickrema, L. C. & Pike, R. N. The initiating proteases of the accompaniment system: authoritative the cleavage. Biochimie 90, 387–395 (2008).

CAS  Google Scholar 

Fuentes-Prior, P. & Salvesen, G. S. The protein structures that appearance caspase activity, specificity, activation and inhibition. Biochem. J. 384, 201–232 (2004).

CAS  PubMed  PubMed Central  Google Scholar 

Wilson, N. S., Dixit, V. & Ashkenazi, A. Afterlife receptor arresting transducers: nodes of allocation in allowed signaling networks. Nature Immunol. 10, 348–355 (2009).

CAS  Google Scholar 

Riedl, S. J. & Salvesen, G. S. The apoptosome: signalling belvedere of corpuscle death. Nature Rev. Mol. Corpuscle Biol. 5, 405–413 (2007).

Google Scholar 

LeMosy, E. K., Tan, Y. Q. & Hashimoto, C. Activation of a protease avalanche circuitous in apery the Drosophila embryo. Proc. Natl Acad. Sci. USA 98, 5055–5060 (2001).

CAS  Google Scholar 

Coussens, L. M., Fingleton, B. & Matrisian, L. M. Cast metalloproteinase inhibitors and cancer: trials and tribulations. Science 295, 2387–2392 (2002).

CAS  PubMed  PubMed Central  Google Scholar 

Overall, C. M. & Kleifeld, O. Towards third bearing cast metalloproteinase inhibitors for blight therapy. Br. J. Blight 94, 941–946 (2006).

CAS  PubMed  PubMed Central  Google Scholar 

Jensen, C., Herold, P. & Brunner, H. R. Aliskiren: the aboriginal renin inhibitor for analytic treatment. Nature Rev. Biologic Discov. 7, 399–410 (2008).

CAS  Google Scholar 

Szelke, M. et al. Almighty new inhibitors of animal renin. Nature 299, 555–557 (1982).

CAS  Google Scholar 

Clozel, J. P. & Fischli, W. Assay of remikiren as the aboriginal orally alive renin inhibitor. Arzneimittelforschung 43, 260–262 (1993).

CAS  Google Scholar 

Sureshkumar, K. K. Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide aggregate therapy. Vasc. Health Accident Manag. 4, 1205–1220 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Thornberry, N. A. & Weber, A. E. Assay of Januvia (sitagliptin), a careful dipeptidyl peptidase IV inhibitor for the assay of blazon 2 diabetes. Curr. Top. Med. Chem. 7, 557–568 (2007).

CAS  Google Scholar 

Weber, A. E. Dipeptidyl peptidase IV inhibitors for the assay of diabetes. J. Med. Chem. 47, 4135–4141 (2004).

CAS  Google Scholar 

Liu, Y. et al. Assay of inhibitors that annotate the role of UCH-L1 action in the H1299 lung blight corpuscle line. Chem. Biol. 10, 837–846 (2003).

CAS  Google Scholar 

Stack, C. M. et al. Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease circuitous in amino acerbic adjustment with abeyant for antimalarial biologic development. J. Biol. Chem. 282, 2069–2080 (2007).

CAS  Google Scholar 

Cunningham, E., Drag, M., Kafarski, P. & Bell, A. Chemical ambition validation studies of aminopeptidase in malaria parasites appliance α-aminoalkylphosphonate and phosphonopeptide inhibitors. Antimicrob. Agents Chemother. 52, 3221–3228 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Maric, S. et al. The M17 leucine aminopeptidase of the malaria bacteria Plasmodium falciparum: the accent of alive armpit metal ions in the bounden of substrates and inhibitors. Biochemistry 48, 5435–5439 (2009).

CAS  Google Scholar 

Skinner-Adams, T. S. et al. Identification of phosphinate dipeptide analog inhibitors directed adjoin the Plasmodium falciparum M17 leucine aminopeptidase as advance antimalarial compounds. J. Med. Chem. 50, 6024–6031 (2007).

CAS  Google Scholar 

Kuebler, P. S. Adjustment of alleviative achievement with thrombolytic agent. US apparent 20080107641 (2007).

Rojkjaer, R. G. ). Pharmaceutical agreement absolute agency VII polypeptides and TAFI polypeptides. US apparent 20030118574 (2002).

Varadarajan, N., Georgiou, G. & Iverson, B. L. An engineered protease that cleaves accurately afterwards sulfated tyrosine. Angew. Chem. Int. Ed Engl. 47, 7861–7863 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Varadarajan, N., Rodriguez, S., Hwang, B. Y., Georgiou, G. & Iverson, B. L. Highly alive and careful endopeptidases with programmed substrate specificities. Nature Chem. Biol. 4, 290–294 (2008).

CAS  Google Scholar 

Madison, E. L., Thanos, C., Ruggles, S. W. & Coughlin, S. Modified agency VII polypeptides and uses thereof. US apparent 20090098103 (2008).

Tanaka, F. Catalytic antibodies as artist proteases and esterases. Chem. Rev. 102, 4885–4906 (2002).

CAS  Google Scholar 

Reverter, D. & Lima, C. D. A base for SUMO protease specificity provided by assay of animal Senp2 and a Senp2–SUMO complex. Anatomy 12, 1519–1531 (2004).

CAS  Google Scholar 

Friedrich, R., Steinmetzer, T., Huber, R., Sturzebecher, J. & Bode, W. The methyl accumulation of Nα(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing able cleavage. J. Mol. Biol. 316, 869–874 (2002).

CAS  Google Scholar 

Lupardus, P. J., Shen, A., Bogyo, M. & Garcia, K. C. Baby molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science 322, 265–268 (2008).

CAS  PubMed  PubMed Central  Google Scholar 

Schecter, I. & Berger, M. On the admeasurement of the alive armpit in proteases. Biochem. Biophys. Res. Commun. 27, 157–162 (1967).

Google Scholar 

Matheson, A.J. & Goa, K.L. Desirudin: a assay of its use in the administration of thrombotic disorders. Drugs 60, 679–700 (2000).

CAS  Google Scholar 

Kakar, P., Watson, T. & Lip, G.Y. Biologic evaluation: rivaroxaban, an oral, absolute inhibitor of activated agency X. Curr. Opin. Investig. Drugs 8, 256–265 (2007).

CAS  Google Scholar 

Eriksson, B.I., Smith, H., Yasothan, U. & Kirkpatrick, P. Dabigatran etexilate. Nature Rev. Biologic Discov. 7, 557–558 (2008).

CAS  Google Scholar 

Matsuo, T., Koide, M. & Kario, K. Development of argatroban, a absolute thrombin inhibitor, and its analytic application. Semin. Thromb. Hemost. 23, 517–522 (1997).

CAS  Google Scholar 

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