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The ability and assurance of anticoagulant analysis for patients with acute, appropriate superficial-vein occlusion in the legs, but after accessory deep-vein occlusion or appropriate pulmonary array at presentation, accept not been established.



In a randomized, double-blind trial, we assigned 3002 patients to accept either fondaparinux, administered subcutaneously at a dosage of 2.5 mg already daily, or placebo for 45 days. The primary ability aftereffect was a blended of afterlife from any account or appropriate pulmonary embolism, appropriate deep-vein thrombosis, or appropriate addendum to the saphenofemoral alliance or appropriate ceremony of superficial-vein occlusion at day 47. The capital assurance aftereffect was above bleeding. The patients were followed until day 77.

The primary ability aftereffect occurred in 13 of 1502 patients (0.9%) in the fondaparinux accumulation and 88 of 1500 patients (5.9%) in the placebo accumulation (relative accident abridgement with fondaparinux, 85%; 95% aplomb breach [CI], 74 to 92; P<0.001). The accident of anniversary basic of the primary ability aftereffect was decidedly bargain in the fondaparinux accumulation as compared with the placebo group, except for the aftereffect of afterlife (0.1% in both groups). The amount of pulmonary array or deep-vein occlusion was 85% lower in the fondaparinux accumulation than in the placebo accumulation (0.2% vs. 1.3%; 95% CI, 50 to 95; P<0.001). Similar accident reductions were empiric at day 77. A absolute of 88 patients would charge to be advised to anticipate one instance of pulmonary array or deep-vein thrombosis. Above bleeding occurred in one accommodating in anniversary group. The accident of austere adverse contest was 0.7% with fondaparinux and 1.1% with placebo.

Fondaparinux at a dosage of 2.5 mg already a day for 45 canicule was able in the analysis of patients with acute, appropriate superficial-vein occlusion of the legs and did not accept austere ancillary effects. (Funded by GlaxoSmithKline; ClinicalTrials.gov number, NCT00443053.)



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